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1994-07-02
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Document 0159
DOCN M9470159
TI Otic administration of amphotericin B 0.25% in sterile water.
DT 9409
AU Kintzel PE; Trausch DE; Copfer AL; Inpatient Pharmacy, University
Medical Center, University of; Arizona Health Sciences Center, Tucson
85724.
SO Ann Pharmacother. 1994 Mar;28(3):333-5. Unique Identifier : AIDSLINE
MED/94250989
AB OBJECTIVE: To report otic administration of parenteral amphotericin B
0.25% in sterile water. CASE SUMMARY: A 44-year-old HIV+ man was
diagnosed with otitis externa. The patient's past medical history was
remarkable for positive Coccidioides immitis serology for more than five
months, essential hypertension, and Barrett's esophagitis. Culture
results from an ear swab revealed 4+ Aspergillus fumigatus and 3+
Staphylococcus, coagulase negative. Antiinfective therapy for the otitis
externa included oral and topical antibacterial and antifungal
medications. Amphotericin B 0.25% in sterile water was prepared by the
pharmacy for topical otic administration. The otic amphotericin B was
dispensed with instructions to refrigerate and assigned a one-week
expiration date. The prescription called for instillation of 1-2 drops
in each ear three times a day. The patient's signs and symptoms of
otitis externa resolved during several weeks of antiinfective therapy.
Topical administration of amphotericin B 0.25% in sterile water was not
associated with any local adverse effects in this patient. DISCUSSION:
The rationale for use of the parenteral amphotericin B formulation to
prepare an otic dosage form, and the rationale for the specific
concentration and expiration date chosen are discussed. CONCLUSIONS:
This patient tolerated topical otic administration of amphotericin B
0.25% in sterile water when administered three times daily.
DE Administration, Topical Adult Amphotericin B/*ADMINISTRATION &
DOSAGE/THERAPEUTIC USE Aspergillosis/*DRUG THERAPY *Aspergillus
fumigatus Case Report Drug Administration Routes Drug Administration
Schedule Ear Canal Human HIV Seropositivity Male Otitis
Externa/*DRUG THERAPY Water JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).